Peer-reviewed article
Ethical considerations in randomized controlled clinical trials
EDICAL PROGRESS requires well-designed and M carefully conducted clinical trials. Such trials may hasten the introduction of truly beneficial therapies while preventing the misuse of nonbeneficial therapies.',* Randomized controlled trials…
EDICAL PROGRESS requires well-designed and M carefully conducted clinical trials. Such trials may hasten the introduction of truly beneficial therapies while preventing the misuse of nonbeneficial therapies.',* Randomized controlled trials (RCT) are, in most cases, the type of clinical trial that is most likely to yield reliable and reproducible clinical knowledge quickly and effi-~i e n t l y . ~ This is because the RCT is the study design least susceptible to methodologic error.4 Study designs using either historic controls or nonrandomized study groups may be plagued by bias which can lead to inaccurate re-sUlts.5,6
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About the author
John D. Lantos is a pediatrician and bioethicist writing on AI in medicine, neonatal intensive care, and end-of-life decisions. His essays appear in JAMA, JAMA Pediatrics, the Hastings Center Report, the New England Journal of Medicine, and Aeon. Read more about John.